Nanomechanical detection of phospholiposome using piezoresistive cantilever sensor

Author

Hyun, S.J. ; Kim, H.S. ; Kim, Y.J. ; Jung, H.I.

Author_Institution

Sch. of Mech. Eng., Yonsei Univ., Seoul, South Korea

Volume

2

fYear

2005

fDate

5-9 June 2005

Firstpage

1792

Abstract

Here, we firstly report the detection of phospholiposomes by the highly sensitive microfabricated piezoresistive cantilever sensor chip and the phosphatidylserine (PS) recognition protein C2A which is chemically immobilized on the sensor surface. The signal created from the bending motion of the piezoresistive cantilever after the phospholiposome attachment has been monitored in real time. And the sensitivity of the sensor was determined judging from the co-relationship between electrical signal and the number of liposome particles.

Keywords

biomolecular electronics; biosensors; microsensors; piezoresistive devices; chemical immobilization; nanomechanical detection; phosphatidylserine recognition; phospholiposome attachment; phospholiposome detection; piezoresistive cantilever sensor; protein C2A; sensor sensitivity; sensor surface; Biosensors; Chemical and biological sensors; Chemical sensors; Etching; Fabrication; Mechanical sensors; Piezoresistance; Proteins; Sensor systems; Surface treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on

Print_ISBN

0-7803-8994-8

Type

conf

DOI

10.1109/SENSOR.2005.1497441

Filename

1497441