Title :
Acoustic plate-wave biosensing
Author :
Costello, Benedict J. ; Martin, Bret A. ; White, Richard M.
Author_Institution :
California Univ., Berkeley, CA, USA
Abstract :
The biosensing potential of a flexural plate-wave delay-line oscillator is described. Experimental results confirm theoretical predictions that the sensor can operate in contact with a liquid and still detect small changes in membrane mass. A response to adsorbed proteins is observed as a prelude to the detection of specific biomolecular reactions and implies that the sensor can be used to monitor specific biomolecular reactions. The delay-line oscillator also provides a tool for monitoring adsorption of molecules at each step of a covalent immobilization process in real time
Keywords :
biological techniques and instruments; biosensors; membranes; molecular biophysics; ultrasonic delay lines; acoustic plate wave biosensing; adsorbed proteins; biomolecular reactions; covalent immobilization process; flexural plate-wave delay-line oscillator; liquid contact; membrane mass; molecule adsorption monitoring; real time; Acoustic sensors; Acoustic waves; Biomembranes; Biosensors; Chemical and biological sensors; Copper; Frequency; Ice thickness; Oscillators; Silicon;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96109
