Title :
A KTAP framework for anylyzing cellular self-repair kinetics under external stress
Author :
Qi, Jinpeng ; Ding, Yongsheng ; Wu, Yizhi ; Zhu, Ying
Author_Institution :
Coll. of Inf. Sci. & Technol., Donghua Univ., Shanghai, China
Abstract :
To analyze different kinetics of cellular responding genome stress under external perturbation circumstances, a mathematical model of cellular self-repair process is proposed by using the Kinetic Theory of Active Particles (KTAP) framework. Under continuous function of ion radiation (IR), the processes of DNA damage and Repair Protein (RP) generation, DSBC syntheses, and cellular toxins accumulation are represented by the particle interactions between the pairs of active molecules within different two sub-systems. Especially, the capability of cellular self-repair mechanisms, cellular activity and genome stability in response to genome stress are analyzed under different IR dose domains.
Keywords :
DNA; biochemistry; biological effects of ionising particles; biomechanics; cellular effects of radiation; genomics; molecular biophysics; proteins; DNA damage; KTAP Framework; Kinetic Theory of Active Particles framework; cellular self-repair kinetics; cellular toxin accumulation; genome stability; genome stress effect; ion radiation dose domains; mathematical model; particle interactions; repair protein generation; Bioinformatics; DNA; Genomics; Kinetic theory; Maintenance engineering; Proteins; Stress; Genome Stress; KTAP; Modelling; Perturbation;
Conference_Titel :
Control Conference (ASCC), 2011 8th Asian
Conference_Location :
Kaohsiung
Print_ISBN :
978-1-61284-487-9
Electronic_ISBN :
978-89-956056-4-6
