Title :
Neuron-based sensors for biochemical quantitation
Author :
Kisaalita, W.S. ; Skeen, R.S. ; Van Wie, B.J. ; Barnes, C.D. ; Fung, S.J. ; Davis, W.C.
Author_Institution :
Washington State Univ., Pullman, WA, USA
Abstract :
Using intracellular recording from freshly dissected Limnea stagnalis neurons and cultured clones for mouse neuroblastoma, N-18 and N1E-115, linear relationships between several analyte concentrations and neuron electrical properties, such as action potential, are obtained. This demonstrates the suitability of neurons as primary transducers in neuron-based sensors. Initial development work that will lead to testing cultured neurons for the detection of monoclonal antibodies is reported
Keywords :
bioelectric potentials; biosensors; chemioception; neurophysiology; Limnea stagnalis neurons; action potential; analyte concentrations; biochemical quantitation; biochips; cultured clones; intracellular recording; monoclonal antibodies; mouse neuroblastoma; neuron electrical properties; neuron-based sensors; primary transducers; Anatomy; Biosensors; Cloning; Delay; Ethanol; Mice; Monitoring; Neurons; Physiology; Transducers;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96118
