Microwave-triggered liposomal drug delivery: investigation of a model drug delivery system

Author

Liburdy, R.P. ; de Manincor, D. ; Sheeler, C.Q. ; Fingado, B.

Author_Institution

Lawrence Berkeley Lab., California Univ., Berkeley, CA, USA

fYear

1989

fDate

9-12 Nov 1989

Firstpage

1163

Abstract

Membrane permeability increases have been observed in liposomal vesicle systems during in vitro exposures to microwave, time-varying magnetic, and static magnetic fields. Cholesterol and other nonphospholipid components of the bilayer are currently being investigated as parameters that play an important role in permeability changes induced by these fields. To determine if liposomal vesicles are responsive to microwave fields under in vivo conditions, liposome vesicles were loaded with the drug gentamicin and used in drug delivery studies. Liposomes were place subcutaneously as a depot in the limb of a rat and the area treated with microwaves. Preliminary studies described here indicate that microwave fields enhance release of gentamicin, as measured by its appearance in the blood stream

Keywords

biological effects of microwaves; biomembrane transport; cholesterol; gentamicin; liposomal vesicle systems; magnetic fields; membrane permeability; microwave-triggered liposomal drug delivery; model drug delivery system; rat limb; subcutaneous depot; Biomembranes; Blood; Drug delivery; In vitro; In vivo; Magnetic field measurement; Magnetic fields; Microwave measurements; Permeability; Time varying systems;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in

Conference_Location

Seattle, WA

Type

conf

DOI

10.1109/IEMBS.1989.96140

Filename

96140