A theoretical model of ventricular reentry and its radiofrequency ablation therapy

We have developed a theoretical model to predict the outcome (i.e. failure/success) of radio-frequency ablation (RFA) therapy via computer calculations of the propagation of action potential in the presence of a ventricular reentry circuit. Our results show that the anatomy (i.e. infarct scar sizes) and the electrical conductivity of the channel between the scars (named isthmus) are critical to inducibility of reentry. Simulations also show that even a small gap in the final lesion relative to the isthmus will result in perpetuation of reentry following RF ablation. The model has potential utility in RF treatment planning for reentry associated with ventricular structural disease (e.g. infarct). A realistic patient-specific model will be parameterized using magnetic resonance imaging (MRI) data to define the tissue anatomy (i.e. infarct areas)