An automated approach for quantification of relative regional myocardial blood flow, using SPECT Tc99m-sestamibi: preliminary validation in a canine model

Author

Liu, Y.H. ; Sinusas, A.J. ; Shi, C.Q.X. ; Shen, M.Y.H. ; Dione, D.P. ; Duncan, J.S. ; Wackers, F.J.Th.

Author_Institution

Dept. of Med., Yale Univ. Sch. of Med., New Haven, CT, USA

fYear

1994

fDate

3-6 Nov 1994

Firstpage

636

Abstract

Computer software for automation of single photon emission computerized tomography (SPECT) quantification was developed. This software includes a simplified automatic edge and center detection algorithm for SPECT images in short axis slices. Furthermore, it provides quantification and display of mean circumferential count profiles. This SPECT quantification algorithm, based on mean count density was validated with postmortem measurements of transmural blood flow, using a canine model of left anterior descending coronary artery (LAD) occlusion. The quantitative results were presented by three dimensional (3D) gray scale cine, static topographic map, and 3D circumferential mean count profiles, and showed good correlation with postmortem relative regional myocardial blood flow

Keywords

blood flow measurement; cardiology; edge detection; medical image processing; single photon emission computed tomography; 3D circumferential mean count profiles; ^99mTc; SPECT Tc99m-sestamibi; Tc; automated approach; automatic center detection algorithm; automatic edge detection algorithm; automation; canine model; computer software; left anterior descending coronary artery occlusion; mean circumferential count profiles; mean count density; postmortem measurements; quantification; quantitative results; relative regional myocardial blood flow; short axis slices; single photon emission computerized tomography; static topographic map; three dimensional gray scale cine; transmural blood flow; Automation; Blood flow; Computed tomography; Computer displays; Density measurement; Detection algorithms; Image edge detection; Optical computing; Single photon emission computed tomography; Software;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.411839

Filename

411839