Title :
Design of potential therapeutic peptides and carriers to inhibit amyloid β peptide aggregation
Author :
Loureiro, Joana A. ; Coelho, Manuel A N ; Rocha, Sandra ; Pereira, Maria Do Carmo
Author_Institution :
Dept. de Eng. Quim., Univ. do Porto, Porto, Portugal
Abstract :
The conformational changes and aggregation of amyloid β peptide (Aβ) are associated to Alzheimer´s disease (AD). The aim of this work is to study the structure and fibril assembly of Aβ in the presence of charged and nonionic amphiphiles, and β-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit Aβ aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).
Keywords :
diseases; drug delivery systems; gene therapy; molecular biophysics; molecular configurations; organic compounds; Alzheimer disease; BBB; amyloid beta aggregation inhibition; amyloid beta conformational changes; amyloid beta fibril assembly; amyloid beta peptide; amyloid beta structure; beta sheet breaker conjugates; beta sheet breaker peptides; brain blood barrier; charged amphiphiles; liposome systems; nonionic amphiphiles; therapeutic carrier design; therapeutic peptide design; Aggregates; Alzheimer´s disease; Biomembranes; Peptides; Proteins; Amyloid beta-peptide; amphiphiles; intermolecular interactions; liposomes; peptides;
Conference_Titel :
Bioengineering (ENBENG), 2012 IEEE 2nd Portuguese Meeting in
Conference_Location :
Coimbra
Print_ISBN :
978-1-4673-4524-8
DOI :
10.1109/ENBENG.2012.6331364
