Title :
Design of a mode of delivery for macrobead transplantation
Author :
Desai, Jagdip ; Jain, Kanti
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
The macrobead, a biohybrid artificial pancreas (BAP), is used to treat type 1 diabetes. A hypothetical human transplantation would require 125 rat equivalent macrobeads. A mode of delivery that allows the placement of several hundred macrobeads into a basket or pouch type device is required. Four commercially available materials were identified as possible candidates for creating a pouch: polyvinyl chloride acrylic copolymer (PVC), polyether sulfone (PES), polyvinylidene difluoride (PVD), and polytetrafluorethylene (PTFE-teflon). Pouches of each material underwent in vivo biocompatibility and in vitro permeability examinations. Based on the results PES and PVD appear suitable for creating a pouch to hold a large number of marobeads
Keywords :
artificial organs; basket-type device; commercially available materials; delivery mode; hypothetical human transplantation; in vitro permeability; in vivo biocompatibility; macrobead transplantation; polyether sulfone; polytetrafluorethylene; polyvinyl chloride acrylic copolymer; polyvinylidene difluoride; pouch type device; rat equivalent macrobeads; type 1 diabetes treatment; Atherosclerosis; Biological materials; Biomembranes; Blood; Diabetes; In vivo; Insulin; Pancreas; Protection; Sugar;
Conference_Titel :
Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast
Conference_Location :
New Brunswick, NJ
Print_ISBN :
0-7803-3204-0
DOI :
10.1109/NEBC.1996.503213
