Correlation of magnetic resonance spectroscopic imaging and intracranial EEG localization of seizures. 7

Two and a half million people in US have epilepsy 600,000 individuals have medically intractable epilepsy. Epilepsy surgery offers an alternative treatment and a potential cure. In certain patients, particularly subjects with normal anatomical MRI, evaluation often includes intracranial electrode recording. Continuous monitoring of electrical signals directly from the brain for periods of 1 to 14 days are performed to record actual seizures that provide more precise localization of seizures. Magnetic resonance spectroscopic imaging (MRSI) offers the potential to localize such regions non-invasively. In this study we present results from a comparison of such abnormal region identification for ten patients from both intracranial electrodes and MRSI. The analysis employed both rigid and non-rigid registration methods, as well as localization of intracranial electrodes from CT images. We found that IcEEG and MRSI localization methods were concordant in all ten subjects