DocumentCode :
1817016
Title :
Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin
Author :
Chen, X. ; Fernando, G.J.P. ; Corbett, H. ; Prow, T.W. ; Crichton, M.L. ; Kendall, M.A.F.
Author_Institution :
Delivery of Drugs & Genes Group (DG), Univ. of Queensland, St. Lucia, QLD, Australia
fYear :
2010
fDate :
22-26 Feb. 2010
Firstpage :
358
Lastpage :
361
Abstract :
We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.
Keywords :
cellular biophysics; coating techniques; coatings; drug delivery systems; drugs; epidemics; skin; antigen; cells; densely packed microprojection patches; dose reduction effects; enhanced vaccine delivery; epidermis; fast evaporation aided coating; pandemic; short microprojection patches; skin; vaccine coating; Arrays; Coatings; Ear; Mice; Proteins; Skin; Vaccines; delivery efficiency; fast evaporation; microprojections; vaccine;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nanoscience and Nanotechnology (ICONN), 2010 International Conference on
Conference_Location :
Sydney, NSW
Print_ISBN :
978-1-4244-5261-3
Electronic_ISBN :
978-1-4244-5262-0
Type :
conf
DOI :
10.1109/ICONN.2010.6045237
Filename :
6045237
Link To Document :
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