Title :
Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample
Author :
Perera, A. ; Buil, A. ; Di Bernardo, M.C. ; Sabater-Lleal, M. ; Pattini, L. ; Souto, J.C. ; Fontcuberta, J. ; Vallverdu, M. ; Soria, J.M. ; Caminal, P.
Author_Institution :
Univ. Politec. de Catalunya, Barcelona
Abstract :
This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.
Keywords :
DNA; genetics; medical computing; molecular biophysics; polymorphism; F7 gene; clustering algorithm; genetic variability; genotype; haplotype configuration; normalized mutual information dissimilarity distance; population genetics literature; single nucleotide polymorphism set; Bioinformatics; Biomedical measurements; Cardiology; Costs; Genetics; Genomics; Humans; Mutual information; Proteins; Sequences; Analysis of Variance; Cluster Analysis; Factor VII; Genotype; Humans; Polymorphism, Single Nucleotide; Thrombophilia;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352238