Title :
The Epitheliome Project: multiscale agent-based modeling of epithelial cells
Author :
Smallwood, Rod ; Holcombe, Mike
Author_Institution :
Dept. of Comput. Sci., Sheffield Univ.
Abstract :
The aim of the Epitheliome Project is to develop a computational model of cell behaviour within the context of tissue architecture, differentiation, wound repair and malignancy. Integration is central to tissue development for skin, integration between mesenchymal and epithelial tissue; at the physical level from focal adhesions and adherens junctions to cytoskeleton to whole tissue; at the signaling level from control of gene expression through to development of gradients controlling histodifferentiation; and integration in the sense of the development of tissues as an emergent property of cell behaviour. An individual-based model of the cell is used, and tissue development is thus a result of the interaction of individual cells. The limit of a large number of individual cells is a continuum model of tissue, and individual cells can contain continuum or differential equation models of cellular mechanisms. The hierarchical modeling paradigm is described
Keywords :
adhesion; cellular biophysics; differential equations; genetics; medical computing; physiological models; skin; Epitheliome Project; adherens; cell behaviour; cell signaling; continuum model; cytoskeleton; differential equation model; epithelial cells; epithelial tissue; focal adhesions; gene expression; hierarchical modeling; histodifferentiation; malignancy; mesenchymal tissue; multiscale agent-based modeling; skin; tissue architecture; tissue differentiation; tissue integration; wound repair; Adhesives; Biological system modeling; Cells (biology); Centralized control; Computational modeling; Computer architecture; Context modeling; Gene expression; Skin; Wounds;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-9576-X
DOI :
10.1109/ISBI.2006.1625043
