DocumentCode :
1818832
Title :
Modeling of regulatory volume decrease in mesangial cells
Author :
Huang, Chien-Jung ; Palant, Carlos E. ; Craelius, William
Author_Institution :
Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA
fYear :
1996
fDate :
14-15 Mar 1996
Firstpage :
111
Lastpage :
112
Abstract :
An electromechanical model, combining stretch-activated ion channels and mechanical function of mesangial cell membrane, was formulated to approach and analyze hypotonically-induced swelling in isolated kidney mesangial cells. Simulation results showed that the osmotic gradient was rapidly nullified by solute efflux and water dilution within 15 seconds, followed by a negative overshooting that gradually returned to the baseline. It is suggested that the reversed osmotic gradient may be partially responsible for volume shrinkage after initial swelling in mesangial cells
Keywords :
biomembrane transport; cellular biophysics; kidney; osmosis; physiological models; shrinkage; swelling; water; animal cells; electromechanical model; hypotonically-induced swelling; initial swelling; isolated kidney mesangial cells; mechanical function; mesangial cell membrane; mesangial cells; negative overshooting; osmotic gradient; regulatory volume decrease; reversed osmotic gradient; simulation results; solute efflux; stretch-activated ion channels; volume shrinkage; water dilution; Animals; Biomedical engineering; Biomembranes; Cells (biology); In vitro; In vivo; Medical simulation; Predictive models; Resists; Robustness;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast
Conference_Location :
New Brunswick, NJ
Print_ISBN :
0-7803-3204-0
Type :
conf
DOI :
10.1109/NEBC.1996.503242
Filename :
503242
Link To Document :
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