Title :
Identification of non-linear models of neural activity in BOLD fMRI
Author :
Jacobsen, Daniel J. ; Madsen, Kristoffer Hougaard ; Hansen, Lars Kai
Author_Institution :
Intelligent Signal Process., Tech. Univ. Denmark, Lyngby
Abstract :
Non-linear hemodynamic models express the BOLD signal as a nonlinear, parametric functional of the temporal sequence of local neural activity. Several models have been proposed for this neural activity. We identify one such parametric model by estimating the distribution of its parameters. These distributions are themselves stochastic, therefore we estimate their variance by epoch based leave-one-out cross validation, using a Metropolis-Hastings algorithm for sampling of the posterior parameter distribution
Keywords :
biomedical MRI; haemodynamics; medical image processing; neurophysiology; parameter estimation; stochastic processes; BOLD fMRI; Metropolis-Hastings algorithm; epoch based leave-one-out cross validation; nonlinear hemodynamic models; posterior parameter distribution; stochastic distributions; temporal neural activity sequence; variance estimation; Blood; Differential equations; Hemodynamics; Jacobian matrices; Neuroimaging; Noise measurement; Parametric statistics; Sampling methods; Signal processing; Stochastic processes;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-9576-X
DOI :
10.1109/ISBI.2006.1625077