Title :
Inferring brain dynamics using granger causality on fMRI data
Author :
Cecchi, Guillermo A. ; Garg, Rahul ; Rao, A. Ravishankar
Author_Institution :
Comput. Biol. Center, IBM T.J. Watson Res. Center, Yorktown Heights, NY
Abstract :
Here we present a scalable method to compute the structure of causal links over large scale dynamical systems that achieves high efficiency in discovering actual functional connections. The method is based on the Granger causality analysis of multivariate linear models, solved by means of a sparse regression approach, and can deal with autoregressive models of more than 10,000 variables.
Keywords :
biomedical MRI; brain; large-scale systems; neurophysiology; Granger causality analysis; autoregressive models; brain dynamics; fMRI data; large scale dynamical systems; multivariate linear model; neurophysiology; sparse regression approach; Biological system modeling; Computational biology; High-resolution imaging; Independent component analysis; Large-scale systems; Magnetic resonance imaging; Mathematical model; Neuroscience; Random variables; Stochastic processes; Functional Imaging; Image interpretation; Magnetic Resonance Imaging;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on
Conference_Location :
Paris
Print_ISBN :
978-1-4244-2002-5
Electronic_ISBN :
978-1-4244-2003-2
DOI :
10.1109/ISBI.2008.4541068