New Physiological Model of Serum Creatine Phosphokinase Activity in Acute Myocardial Infarction. --- Estimation of the Total Creatine Phosphokinase Release

Author

Kitawaki, T. ; Oka, H. ; Kusachi, S. ; Himeno, R.

Author_Institution

Okayama Univ., Okayama

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

912

Lastpage

915

Abstract

In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.

Keywords

biomedical measurement; blood; cardiology; cellular biophysics; diseases; enzymes; molecular biophysics; physiological models; acute myocardial infarction; blood sampling; enzyme; muscle cells; muscle contraction; physiological model; serum creatine phosphokinase; Ambient intelligence; Arteries; Biochemistry; Biomembranes; Blood flow; Cells (biology); Frequency estimation; Muscles; Myocardium; Sampling methods; Aged; Aged, 80 and over; Biological Markers; Computer Simulation; Creatine Kinase; Diagnosis, Computer-Assisted; Enzyme Activation; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Cardiovascular; Myocardial Infarction; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4352439

Filename

4352439