Title :
Characterization of spatial ordering of corneal stroma fibrils
Author :
Freund, D.E. ; Burlina, P. ; Banerjee, A.
Author_Institution :
Appl. Phys. Lab., Johns Hopkins Univ., Baltimore, MD
Abstract :
The quantitative characterization of the cornea´s ultrastructure is an important component in clinical studies and ophthalmologic research for investigating various corneal pathologies such as Fuch´s dystrophy, bullous keratopathy, and macular corneal dystrophy. The spatial ordering of the stromal fibrils is a good predictor of corneal transparency and light scattering. In this paper this structure is characterized by estimating the probability density function (PDF) associated with some features of the radial distribution function of fibrils seen in electron micrographs of the stroma. A method derived from the support vector data description (SVDD) is used to estimate this PDF. Experiments using electron micrographs of normal and swollen rabbit corneas are used to illustrate the approach.
Keywords :
biomedical measurement; diseases; electron microscopy; eye; light scattering; probability; support vector machines; Fuch dystrophy; bullous keratopathy; cornea ultrastructure; corneal stroma fibrils; corneal transparency; electron micrographs; light scattering; macular corneal dystrophy; probability density function; radial distribution function; stroma; support vector data description; swollen rabbit corneas; Cornea; Crystallization; Distribution functions; Electrons; Laboratories; Light scattering; Optical scattering; Pathology; Physics; Rabbits; PDF estimation; corneal pathologies support vector methods; fibril ordering;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on
Conference_Location :
Paris
Print_ISBN :
978-1-4244-2002-5
Electronic_ISBN :
978-1-4244-2003-2
DOI :
10.1109/ISBI.2008.4541158
