Title :
A Mathematical Model of the Cardiovascular System under Exercise
Author :
Lu Wang ; Su, S.W. ; Chan, G.S.H. ; Celler, B.G.
Author_Institution :
Univ. of New South Wales, Sydney
Abstract :
A mathematical model, based on our previous pulsatile nonlinear multi-element cardiovascular model, was tested and improved to study cardiovascular response under graded exercise levels. Ten healthy subjects were studied using cycle-ergometry exercise test with constant workloads ranging from 25 Watt to 125 Watt. Breath by breath gas exchange, heart rate, cardiac output, stroke volume and blood pressure were measured at each stage. Based on the experimental data, firstly we proved that our previous model is capable to regenerate the cardiovascular variables observed in the subjects under different exercise levels. Secondly, we improved the model by incorporating a robust and efficient function to estimate metabolic demand. Then the new model can estimate both cardiovascular variables and metabolic demand with its simulation results within the range of SD (Standard Deviation, N=10) of the experimental data.
Keywords :
blood pressure measurement; cardiovascular system; electrocardiography; physiological models; ECG; blood pressure; breath by breath gas exchange; cardiac output; cardiovascular system; cycle-ergometry exercise test; electrocardiography; graded exercise levels; heart rate; mathematical model; power 25 W to 125 W; pulsatile nonlinear multielement cardiovascular model; stroke volume; Biomedical monitoring; Blood pressure; Cardiology; Cardiovascular system; Electrocardiography; Heart rate; Mathematical model; Pressure measurement; Testing; Ultrasonic variables measurement; Adult; Blood Pressure; Cardiac Output; Cardiovascular Physiological Phenomena; Computer Simulation; Exercise Test; Female; Heart Rate; Humans; Male; Models, Cardiovascular; Oxygen Consumption; Physical Exertion; Stroke Volume;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352466
