Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

Author

Incerti, S. ; Barberet, Ph. ; Villeneuve, R. ; Aguer, P. ; Gontier, E. ; Michelet-Habchi, C. ; Moretto, Ph. ; Nguyen, D.T. ; Pouthier, T. ; Smith, R.W.

Author_Institution

Bordeaux I Univ., Gradignan, France

Volume

3

fYear

2003

fDate

19-25 Oct. 2003

Firstpage

1759

Abstract

Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high LET ionising radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few microns, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium.

Keywords

Monte Carlo methods; biological effects of ionising particles; biology computing; cellular effects of radiation; ion beam effects; 3.5 MV; CENBG microbeam line; GEANT4; Van de Graaff accelerator; alpha particles; biological samples; cellular irradiation; high LET ionising radiation; light-ion microbeams; radiobiological effects; single protons; Alpha particles; Biological system modeling; Collimators; Counting circuits; Magnetic flux; Object oriented modeling; Particle beam measurements; Particle beams; Protons; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2003 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8257-9

Type

conf

DOI

10.1109/NSSMIC.2003.1352219

Filename

1352219