DocumentCode :
1826732
Title :
Double-pole in closed-loop minimal model of insulin kinetics
Author :
Arundel, Philip ; Allott, Christopher ; Watson, Edmund
Author_Institution :
AstraZeneca R&D, Macclesfield, UK
fYear :
2010
fDate :
7-10 Sept. 2010
Firstpage :
85
Lastpage :
90
Abstract :
In the simplest version of minimal model the glucose and insulin levels are provided in the form of lookup tables. When insulin accumulation is presented as a differential equation, the insulin production rate appears increasing linearly with time. This has a limited physiological basis and could be unstable in some conditions. It is shown here that the insulin compartment can be modelled as having a double-pole which naturally produces the time term, accompanied by a decaying exponential for insulin accumulation rate. In a closed-loop configuration this model produces the `shoulder´ often seen in insulin concentration- time profiles.
Keywords :
closed loop systems; differential equations; physiology; sugar; table lookup; closed-loop configuration; closed-loop minimal model; differential equation; double-pole; exponential decaying; glucose levels; insulin accumulation rate; insulin compartment; insulin concentration-time profiles; insulin kinetics; insulin levels; insulin production rate; lookup tables; physiological basis; closed-loop; insulin; models; poles; simulation;
fLanguage :
English
Publisher :
iet
Conference_Titel :
Control 2010, UKACC International Conference on
Conference_Location :
Coventry
Electronic_ISBN :
978-1-84600-038-6
Type :
conf
DOI :
10.1049/ic.2010.0261
Filename :
6490719
Link To Document :
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