Title :
Immunological Response Induced by Alternated Cooling and Heating of Breast Tumor
Author :
Jiaxiang Dong ; Ping Liu ; Aili Zhang ; Xu, L.X.
Author_Institution :
Shanghai Jiao Tong Univ., Shanghai
Abstract :
A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.
Keywords :
biological organs; cooling; gynaecology; heating; hyperthermia; surgery; tumours; 4T1 murine mammary carcinoma; antitumor response; breast tumor; cooling; cryosurgery; heating; immunocytes; immunological response; in-situ thermal physical method; local hyperthermia; reimplantation; synergistic effect; tumor debris; tumor rejection; tumor therapy; Animals; Breast neoplasms; Breast tumors; Cooling; Heating; Hyperthermia; Immune system; Medical treatment; Metastasis; Mice; Animals; Cold Temperature; Female; Hot Temperature; Hyperthermia, Induced; Hypothermia, Induced; Immunity, Innate; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352583