Aligning emission tomography and MRI images by optimizing the emission-tomography image reconstruction objective function

Author

Bowsher, James E. ; DeLong, David M. ; Turkington, Timothy G. ; Jaszczak, Ronald J.

Author_Institution

Dept. of Radiol., Duke Univ. Med. Center, Durham, NC, USA

Volume

4

fYear

2003

fDate

19-25 Oct. 2003

Firstpage

2562

Abstract

An important approach to reconstruction of PET and SPECT images is to utilize high-resolution information from registered MRI or CT images. Herein, a PET/SPECT image-reconstruction objective function is presented which includes parameters for the alignment between PET/SPECT and MRI/CT. A Levenberg-Marquardt estimation procedure is developed. An anecdotal evaluation is performed with computer-simulated PET/SPECT projection data for a brain phantom. The simulation models a spatial blur of 2 mm FWHM and utilizes 1-mm-wide PET/SPECT voxels. After two iterations, translational alignment errors are well under 0.1 mm and rotational errors are fractions of a degree.

Keywords

biomedical MRI; brain; estimation theory; image reconstruction; optimisation; phantoms; positron emission tomography; single photon emission computed tomography; CT images; Levenberg-Marquardt estimation; MRI images; PET images; SPECT images; anecdotal evaluation; brain phantom; computer-simulated PET/SPECT projection data; emission tomography alignment; emission-tomography image reconstruction objective function; optimisation; rotational errors; translational alignment errors; Biomedical imaging; Computed tomography; Computer errors; Image reconstruction; Image segmentation; Imaging phantoms; Magnetic resonance imaging; Performance evaluation; Positron emission tomography; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2003 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8257-9

Type

conf

DOI

10.1109/NSSMIC.2003.1352413

Filename

1352413