Title :
The effect of parameter uncertainty on a novel insulin bolus calculator
Author :
Palma, Rodrigo ; Edgar, Thomas F.
Author_Institution :
Dept. of Chem. Eng., Univ. of Texas at Austin, Austin, TX, USA
Abstract :
A simple control law is derived from the eponymous Bergman Minimal Model with the aim of implementing patient specific insulin injections. The Fisher Information Matrix is used to form an approximate necessary condition for the a posteriori identifiability of the Bergman Minimal Model´s parameters from home-use continuous glucose measurements. It is shown that despite parameter uncertainty control moves based on the control law are not subject to physiologically significant variability.
Keywords :
matrix algebra; maximum likelihood estimation; medical control systems; Fisher information matrix; a posteriori identifiability; eponymous Bergman minimal model; home-use continuous glucose measurements; insulin bolus calculator; parameter uncertainty control; patient specific insulin injections; biomedical systems; identifiability; physiological models; sensitivity analysis; system identification;
Conference_Titel :
Control 2010, UKACC International Conference on
Conference_Location :
Coventry
Electronic_ISBN :
978-1-84600-038-6
DOI :
10.1049/ic.2010.0387
