DocumentCode :
1830075
Title :
Extraction of blood pool in dynamic O-15 water PET with slow-infusion using factor analysis
Author :
Kim, Kyeong Min ; Watabe, Hiroshi ; Kawachi, Naoki ; Iida, Hidehiro
Author_Institution :
Dept. of Investigative Radiol., Nat. Cardiovascular Center, Osaka, Japan
Volume :
4
fYear :
2003
fDate :
19-25 Oct. 2003
Firstpage :
2640
Abstract :
Accurate measurement of myocardial blood flow (MBF) can be achieved noninvasively by using dynamic PET with a slow-infusion of O-15 water incorporating O-15 CO gas scan, which is used for identification of myocardium regions to obtain an accurate input function. Although there have been studies using PET with bolus-injection, the applicability of factor analysis (FA) to slow-infused water data has not been examined yet. In this study, we investigated a method for extracting blood pool activities from dynamic water image with slow-infusion using FA. A dynamic PET scan was performed with slow-infusion of water, after a static CO scan. Both components of blood pool and myocardial tissue were separated from the acquired dynamic water image using FA. Time-activity curve (TAC) of blood pool and myocardium were extracted, and the images of blood volume (VB) and extravascular tissue density (Dev) were generated, respectively. The TAC shape of blood pool was agreed to that of true input function. The effect of spillover from blood pool to myocardium was dramatically eliminated in TAC shape. The both images of VB and myocardium by FA were similar with VB image by CO and washout-phase image of dynamic data, respectively. Both Dev image by CO image and FA were also comparable in terms of spatial distribution and count scale. This approach incorporating factor analysis could be useful for improved quantitation of MBF using simplified acquisition protocol without CO scan.
Keywords :
biological tissues; blood flow measurement; cardiology; medical image processing; positron emission tomography; radioactive tracers; radioactivity measurement; O-15 CO gas scan; acquisition protocol; blood pool activity extraction; blood volume image; bolus-injection; count scale; dynamic O-15 water PET; dynamic water image; extravascular tissue density image; factor analysis; input function; myocardial blood flow; myocardial tissue; myocardium region identification; noninvasive measurement; slow-infusion; spatial distribution; spillover effect; static CO scan; time-activity curve; washout-phase image; Blood flow; Cardiology; Data mining; Fluid flow measurement; Image analysis; Myocardium; Positron emission tomography; Protocols; Radiology; Shape;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium Conference Record, 2003 IEEE
ISSN :
1082-3654
Print_ISBN :
0-7803-8257-9
Type :
conf
DOI :
10.1109/NSSMIC.2003.1352431
Filename :
1352431
Link To Document :
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