Title :
A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
Author :
Xiwei Huang ; Fei Wang ; Jing Guo ; Mei Yan ; Yu Hao ; Kiat Seng Yeo
Author_Institution :
Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore, Singapore
Abstract :
A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps.
Keywords :
CMOS image sensors; DNA; biosensors; ion sensitive field effect transistors; semiconductor device noise; CMOS ion-image sensor; accurate high-throughput DNA sequencing; correlated double sampling readout; dual-mode sensing; ion-sensitive field-effect transistor; local pH; optical contact imaging; pixel-to-pixel ISFET threshold voltage mismatch; standard CMOS image sensor; suppressed fixed-pattern-noise; Arrays; CMOS integrated circuits; DNA; Sensitivity; Sensors; Sequential analysis; Standards; CDS; CIS; DNA sequencing; ISFET; contact imaging; pH detection;
Conference_Titel :
VLSI Circuits Digest of Technical Papers, 2014 Symposium on
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-4799-3327-3
DOI :
10.1109/VLSIC.2014.6858409
