Title :
An implantable continuous glucose monitoring microsystem in 0.18µm CMOS
Author :
Nazari, Masoud Honarvar ; Mujeeb-U-Rahman, Muhammad ; Scherer, Axel
Author_Institution :
California Inst. of Technol., Pasadena, CA, USA
Abstract :
We present a fully implantable subcutaneous continuous glucose monitoring (CGM) microsystem on CMOS platform. The proposed design incorporates electrochemical sensing technique using an ultra-low-power potentiostatic system. It is wirelessly powered through an inductive coupling link at 900MHz and supports bidirectional data communication with an external reader. A low-power potentiostat and a dual-slope ADC record the on-chip sensor signal. Pt and Ag/AgCl on-chip electrodes are post-fabricated and functionalized in situ by glucose oxidase enzyme to enable glucose measurement. The 1.4×1.4×0.25mm3 prototype fabricated in a 0.18μm CMOS technology was validated in glucose measurements. Total power consumption of the system is 6μW.
Keywords :
CMOS integrated circuits; analogue-digital conversion; biomedical electronics; electrochemical sensors; low-power electronics; micromechanical devices; platinum; silver compounds; Ag-AgCI; CGM microsystem; CMOS technology; Pt; bidirectional data communication; dual-slope ADC; electrochemical sensing technique; external reader; fully implantable subcutaneous continuous glucose monitoring; glucose measurement; glucose oxidase enzyme; inductive coupling link; on-chip electrodes; on-chip sensor signal; power 6 muW; size 0.18 mum; ultra-low-power potentiostatic system; Abstracts; Frequency conversion; Frequency modulation; Implants; Sugar; Switches; System-on-chip;
Conference_Titel :
VLSI Circuits Digest of Technical Papers, 2014 Symposium on
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-4799-3327-3
DOI :
10.1109/VLSIC.2014.6858432
