Title :
Behavioral Study of Calorie-restricted Rats from Early Old Age
Author :
Geng, Y.Q. ; Guan, J.T. ; Xu, M.Y. ; Fu, Y.C.
Author_Institution :
Shantou Univ., Shantou
Abstract :
This paper aims to investigate the effect of Calorie Restriction (CR) on learning and memory ability of early aged rats. Methods: 18-month rats were subjected to restricted intake by 60% comparing with that of rats fed ad libitum (AL) for 6 months. We compared the overall health status, including survival rate and locomotor activity by open-field test. We examined the spatial cognition ability of the rats by Morris Water Maze.Our results showed that CR rats had higher survival rate and spontaneous locomotor activity compared with AL rats. CR rats slowed the inability of spatial learning and reference memory. These findings demonstrated that CR in early old rats delayed the declination of spatial cognition. I.
Keywords :
biomechanics; cognition; neurophysiology; Morris Water Maze; behavioral study; calorie-restricted rats; early aged rats; learning; locomotor activity; memory; open-field test; spatial cognition ability; survival rate; Aging; Animals; Chromium; Cognition; Data analysis; Delay; Navigation; Rats; Target tracking; Testing; Aging; Animals; Behavior, Animal; Body Weight; Caloric Restriction; Cognition; Energy Intake; Feeding Behavior; Locomotion; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352809
