Title :
A bio-inspired closed-loop insulin delivery based on the silicon pancreatic beta-cell
Author :
Ho, Mel ; Georgiou, Pantelis ; Singhal, Suket ; Oliver, Nick ; Toumazou, Chris
Author_Institution :
Inst. of Biomed. Eng., Imperial Coll. London, London
Abstract :
This demonstration presents the first bio-inspired approach to glucose management of type-1 diabetic patients using a real-time closed-loop insulin delivery system. The delivery system consists of a glucose biosensor, used with the silicon beta-cell to drive a motorized pump. Glucose-induced bursting of beta cells in the pancreas are used to control the insulin secretion in our bodies. A low-power implementation of these metabolic cells in silicon is achieved resulting in efficient glucose control.
Keywords :
biosensors; closed loop systems; diseases; patient treatment; silicon; sugar; bioinspired closed-loop insulin delivery; glucose biosensor; glucose control; glucose management; insulin secretion control; motorized pump; pancreas; silicon beta-cell; silicon pancreatic beta-cell; type-1 diabetic patients; Biosensors; Blood; Cardiac disease; Cells (biology); Diabetes; Electrodes; Insulin; Pancreas; Silicon; Sugar;
Conference_Titel :
Circuits and Systems, 2008. ISCAS 2008. IEEE International Symposium on
Conference_Location :
Seattle, WA
Print_ISBN :
978-1-4244-1683-7
Electronic_ISBN :
978-1-4244-1684-4
DOI :
10.1109/ISCAS.2008.4541602
