Title :
An in computo investigation of the Landau-Kleffner syndrome
Author :
Bonjean, M. ; Phillips, C. ; Thien Thanh Dang Vu ; Sepulchre, R. ; Maquet, P.
Author_Institution :
Univ. of Liege, Liege
Abstract :
We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
Keywords :
brain; diseases; neurophysiology; physiological models; Landau-Kleffner syndrome; cortex; epileptic discharges; thalamus; Biomedical engineering; Brain modeling; Circuits; Computational modeling; Computer simulation; Cyclotrons; Electroencephalography; Epilepsy; Neurons; Surfaces; Cerebral Cortex; Computer Simulation; Humans; Landau-Kleffner Syndrome; Thalamus;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352893
