Title :
Quantitative analysis method to evaluate optical clearing effect of skin using a hyperosmotic chemical agent
Author :
Jinhee Yoon ; Taeyoon Son ; Byungjo Jung
Abstract :
Light penetration depth in highly scattering tissues can be increased by using hyperosmotic chemical agents such as glycerol, PEG (polyethylene glycol) and glucose. Previous many studies used OCT, spectrometer, integrating method to quantitatively evaluate the optical clearing effect of skin. In this study, we show the optical clearing effect of skin using glycerol and suggest a new quantitative analysis method to evaluate the spatial optical clearing effect of skin using glycerol.
Keywords :
biomedical optical imaging; optical tomography; organic compounds; patient diagnosis; skin; OCT; glucose; glycerol; highly scattering tissues; hyperosmotic chemical agent; integrating method; light penetration depth; optical clearing effect; polyethylene glycol; quantitative analysis; skin; spectrometer; Adaptive optics; Biomedical imaging; Biomedical optical imaging; Chemical analysis; Optical filters; Optical imaging; Optical microscopy; Optical scattering; Polarization; Skin; Algorithms; Animals; Dermoscopy; Image Interpretation, Computer-Assisted; Photosensitizing Agents; Refractometry; Reproducibility of Results; Sensitivity and Specificity; Skin Physiological Phenomena; Swine; Water-Electrolyte Balance;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4353047
