Title :
An integrated patch-clamp amplifier for high-throughput planar patch-clamp systems
Author :
Weerakoon, Pujitha ; Culurciello, Eugenio ; Klemic, Kate ; Sigworth, Fred J.
Author_Institution :
Electr. Eng. Dept., Yale Univ., New Haven, CT
Abstract :
We present a fully-integrated implementation of a patch-clamp measurement system. The system was implemented in a 0.5mum silicon-on-sapphire process and is capable of recording cell membrane currents up to plusmn20nA, with a rms noise of 5pA at 10kHz bandwidth. The system can compensate for the capacitance and resistance of the planar electrode, up to 20pF and 4MOmega respectively. The die size is 1150 by 700mum. The power consumption is 3.3mW at 3.3V. The integrated patch- clamp system will be used to fabricate high-throughput planar patch-clamp systems.
Keywords :
amplifiers; biosensors; digital integrated circuits; electrodes; power consumption; sapphire; silicon; Si-Al2O3; cell membrane current recording; fully-integrated implementation; high-throughput planar patch-clamp systems; integrated patch-clamp amplifier; patch-clamp biosensors; planar electrode capacitance; planar electrode resistance; power consumption; silicon-on-sapphire process; size 0.5 mum; Bandwidth; Biomembranes; Cells (biology); Current measurement; Electric variables measurement; Electrodes; Integrated circuit measurements; Monitoring; Parasitic capacitance; Radiofrequency amplifiers;
Conference_Titel :
Circuits and Systems, 2008. ISCAS 2008. IEEE International Symposium on
Conference_Location :
Seattle, WA
Print_ISBN :
978-1-4244-1683-7
Electronic_ISBN :
978-1-4244-1684-4
DOI :
10.1109/ISCAS.2008.4541791
