Title :
The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant
Author :
Lakerveld, Richard ; Benyahia, Brahim ; Heider, Patrick L. ; Zhang, Haijun ; Wolfe, Adriane ; Testa, C. ; Ogden, Sean ; Hersey, Devin R. ; Mascia, Salvatore ; Evans, James M. B. ; Braatz, Richard ; Barton, Paul I.
Author_Institution :
Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA
Abstract :
Continuous manufacturing has the potential to provide substantial improvements to the manufacturing of pharmaceutical products compared to traditional batch-wise manufacturing. A key challenge is the development of effective control strategies for this new type of process. This contribution presents the experimental application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant that produces a pharmaceutical product from start to finish in a continuous fashion. The performance of the automated control loops demonstrate the maintenance of the critical material attributes close to their desired setpoints for a sustained period of operation.
Keywords :
industrial plants; pharmaceutical industry; automated control loops; automated plant-wide control strategy; batch-wise manufacturing; continuous manufacturing; continuous pharmaceutical pilot plant; material attributes; pharmaceutical product; Compounds; Crystallizers; Pharmaceuticals; Process control; Quality assessment; Solvents; Control applications; Manufacturing systems; Process control;
Conference_Titel :
American Control Conference (ACC), 2014
Conference_Location :
Portland, OR
Print_ISBN :
978-1-4799-3272-6
DOI :
10.1109/ACC.2014.6858854
