Title :
Genetically-engineered whole-cell bioreporters on integrated circuits for environmental monitoring
Author :
Bull, N.D. ; Islam, S.K. ; Blalock, B.J. ; Ripp, S. ; Moser, S. ; Sayler, G.S.
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of Tennessee, Knoxville, TN
Abstract :
A bioluminescent bioreporter integrated circuit (BBIC) biosensor for environmental monitoring is presented. The bioluminescent bioreporters are bacteria that can be genetically altered to achieve bioluminescence when in contact with a targeted substance. The bioreporters are placed on a microluminometer. The microluminometer includes integrated photodiodes and signal processing circuits and is realized in a standard CMOS process. The BBIC can detect luminescence from as few as 5000 fully induced Pseudomonas fluorescene 5RL bacteria and provides a integrated biosensor platform for environmental and food/water safety monitoring.
Keywords :
CMOS integrated circuits; bioluminescence; biosensors; cellular biophysics; microorganisms; photodiodes; signal processing; Pseudomonas fluorescene 5RL bacteria; bioluminescence; bioluminescent bioreporter integrated circuit biosensor; environmental monitoring; genetically-engineered whole-cell bioreporters; integrated photodiodes; microluminometer; signal processing circuits; standard CMOS process; Bioluminescence; Biomedical signal processing; Biosensors; CMOS process; Circuits; Fluorescence; Luminescence; Microorganisms; Monitoring; Photodiodes;
Conference_Titel :
Circuits and Systems, 2008. ISCAS 2008. IEEE International Symposium on
Conference_Location :
Seattle, WA
Print_ISBN :
978-1-4244-1683-7
Electronic_ISBN :
978-1-4244-1684-4
DOI :
10.1109/ISCAS.2008.4541838
