A Dynamical Model on the Network of p53-Mdm2 Feedback Loop Regulated by p14/19ARF

Author

Hui Liu ; Ying-Rong Han ; Yong Zhan ; Ya-Fei Chen ; Yu-Hong Zhang ; Hui Yu ; Tong-Jun Zhao ; Yi-Zhong Zhuo

Author_Institution

Hebei Univ. of Technol., Tianjin

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

4235

Lastpage

4238

Abstract

Base on new experimental results, we give a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARR The oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors among p53, Mdm2 and P14/19ARR The dynamical model and its numerical results will help us understand the oscillatory behavior among other network of different proteins.

Keywords

cancer; cellular biophysics; molecular biophysics; proteins; tumours; Mdm2 protein; biological cells; cancer; dynamical model; feedback loop; human malignancies; oscillatory behaviors; p14/19 ARF protein; p53 protein; protein network; tumor suppressor protein; Cancer; DNA; Feedback loop; Fingers; Humans; Negative feedback loops; Neoplasms; Protein engineering; RNA; Sequences; Animals; Biological Clocks; Humans; Models, Biological; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353271

Filename

4353271