Surface plasmon resonance biosensor based on compact discs

This paper presented a grating-coupled surface plasmon resonance (SPR) biosensor based on the structure of compact discs (CDs). The reflectance graph with incidence angle is simulated according to the modified CD. In order to verify how the angle shift of SPR depends on a bio-molecular layer, a protein of bovine serum albumin (BSA) is employed as a target to test the sensitivity of the CD biosensor. Although the SPR angle and the reflectivity from the simulation differed slightly with those from the measurement, the direction and the quantities of angle shift are quite consistent with its measured results and also proportional to the thickness of bio-layer. The preliminary results showed that SPR bio-sensors based on CDs promise to be a low-cost, rapid, high throughput screening sensor product for biological molecules detection.