Demonstration of implantable CMOS image sensors for functional brain imaging

We have developed implantable complementary -metal-oxide-semiconductor (CMOS) imaging devices for brain functional imaging (Fig.1) [1]. With the device, it is possible to perform fluorescence or absorption imaging and observe various neural activities of the mouse brain in a freely moving state [2, 3]. The device comprises a CMOS image sensor, and LEDs as excitation or illumination light sources. The pixel array is coated with absorption filter for excitation light rejection in the case of fluorescence imaging. It is expected that brain imaging in a freely moving mouse will be possible to elucidate relations between neural activities and behaviors.