Title :
MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer
Author :
Xhemo, E. ; Fajac, A. ; Boire, J.-Y. ; Levy, P.P.
Author_Institution :
Tenon Hosp., Paris
Abstract :
This paper presents the Generalized CaseView method applied to the study of polymorphisms of MDR1 (Multi Drug Resistant), a gene coding for a trans-membrane transporting protein. The data base contains Single nucleotide polymorphisms, their positions in cDNA, and the Area Under the Curve of drugs concentrations. The generalized CaseView method permits a compact visualization of these data. The main result is that pharmacokinetics of some anticancer drugs depends on the genotype.
Keywords :
biotransport; cancer; cellular biophysics; drug delivery systems; mammography; molecular biophysics; pharmaceuticals; ABCB1 gene; MDR1 gene; MDRView; anticancer drugs; breast cancer; compact visualization; drugs concentrations; gene coding; generalized caseview method; infoxel; multi drug resistant; pharmacokinetics; polymorphism visualization; transmembrane transporting protein; Bioinformatics; Breast cancer; Data visualization; Drugs; Genomics; Hospitals; Materials reliability; Predictive models; Protein engineering; Public healthcare; ABCB1; MDR1; data base; generalized CaseView; infoxel; polymorphism; visualization; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Doxorubicin; Female; Humans; P-Glycoprotein; Polymorphism, Single Nucleotide; Software; Taxoids;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4353362
