Ultra low-noise electrophysiology amplifier on a chip

Author

Crescentini, M. ; Bennati, M. ; Tartagni, Marco

Author_Institution

Dept. of Electr. Electron. & Inf. Eng. “G. Marconi”, Univ. of Bologna, Cesena, Italy

fYear

2014

fDate

22-24 Oct. 2014

Firstpage

276

Lastpage

279

Abstract

This paper presents a novel continuous time (CT) - discrete time (DT) current amplifier for electrophysiology. The architecture aims to bring together advantages from both CT and DT approaches, which are high bandwidth and low noise, respectively. The low-noise current amplifier has been implemented in 0.35 μm CMOS technology, showing input-referred noise as low as 4 fA/√Hz. It allows current recording up to 10 kHz consuming about 35 mW. The system has been tested and demonstrated through recording of ion-channels activity.

Keywords

CMOS integrated circuits; amplifiers; bioelectric potentials; biological techniques; biomembrane transport; continuous time systems; discrete time systems; electric current measurement; lab-on-a-chip; noise; CMOS technology; CT -DT current amplifier architecture; continuous time-discrete time current amplifier; current recording; electrophysiology chip; high-bandwidth current amplifier; input-referred noise; ion channel activity recording; low-noise current amplifier; power 35 mW; size 0.35 mum; ultra low-noise electrophysiology amplifier; Bandwidth; Biosensors; CMOS integrated circuits; Capacitance; Current measurement; Monitoring; Noise; Current amplifier; bilayer lipid membrane; ion channel; noise; sensor interface;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE

Conference_Location

Lausanne

Type

conf

DOI

10.1109/BioCAS.2014.6981716

Filename

6981716