Title :
Flow cytometer-on-a-chip
Author :
Boser, B.E. ; Murali, P.
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of California, Berkeley, Berkeley, CA, USA
Abstract :
Substituting superparamagnetic beads for fluorescent labels used in standard flow cytometry facilitates monolithic integration in a standard 180nm CMOS process without external components. The lack of background eliminates the need for preprocessing, making this platform ideal for point-of-care applications. Differentiation of magnetic bead labels based on ferromagnetic resonance enables assays with more than one biomarker.
Keywords :
CMOS integrated circuits; bioMEMS; biomagnetism; biomedical measurement; cellular biophysics; ferromagnetic resonance; lab-on-a-chip; magnetic particles; microfluidics; patient care; superparamagnetism; assay biomarker; external component; ferromagnetic resonance; flow cytometer-on-a-chip; fluorescent label; magnetic bead label differentiation; monolithic integration; point-of-care application; preprocessing; size 180 nm; standard CMOS process; standard flow cytometry; superparamagnetic bead; Coils; Computer architecture; Detectors; Magnetic circuits; Magnetic domains; Magnetic resonance; Microprocessors;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE
Conference_Location :
Lausanne
DOI :
10.1109/BioCAS.2014.6981767
