Title :
Unidirectional cellular durotaxis via microfabricated posts of varying anisotropy
Author :
Sochol, Ryan D. ; Higa, Adrienne T. ; Janairo, Randall R R ; Chou, Annie ; Li, Song ; Lin, Liwei
Author_Institution :
Berkeley Sensor & Actuator Center, Univ. of California at Berkeley, Berkeley, CA, USA
Abstract :
This paper presents unprecedented accomplishments toward unidirectional guidance of cellular migration via durotaxis-based microtopography. In contrast to previous efforts, micropost arrays of varying anisotropy (muPVAs) optimize unidirectional control of cell migration through dual axis durotaxis cues which restrict movement in the lateral direction in addition to promoting migration in the direction of increasing micropost stiffness. Preliminary results show 79% of bovine aortic endothelial cells (BAECs) cultured on muPVA substrates migrated within plusmn60deg of the direction of increasing micropost anisotropy. muPVAs offer a simple, yet powerful technique for enabling unidirectional control of cellular migration for a variety of applications in tissue engineering, biomaterials, and medical device implantation.
Keywords :
biomedical materials; cellular transport; prosthetics; tissue engineering; biomaterials; bovine aortic endothelial cells; cellular migration; dual axis durotaxis cues; durotaxis-based microtopography; medical device implantation; micropost anisotropy; tissue engineering; unidirectional cellular durotaxis; Actuators; Anisotropic magnetoresistance; Biological processes; Bovine; Cells (biology); Electrochemical machining; Fabrication; Resists; Tissue engineering; Wounds; Cell Migration; Durotaxis; Mechanotaxis; Micropillars; Microposts; Microtopography;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285397
