DocumentCode :
1852527
Title :
Biomedical microdevice for analyzing the effect of electrochemotherapy on cancer cells
Author :
Choi, Youn-Suk ; Kim, Hong-Bae ; Kim, Seung-Hoon ; Choi, Jaekyu ; Park, Je-Kyun
Author_Institution :
Dept. of Bio & Brain Eng., KAIST, Daejeon, South Korea
fYear :
2009
fDate :
21-25 June 2009
Firstpage :
2358
Lastpage :
2361
Abstract :
A microfabricated cell-based testing device for electrochemotherapy (ECT) which mimics a clinical electroporator of circular needle-array has been developed while keeping the similarity of electric field strength distribution. Until now, the performances between the electroporators of two- and six-needle circular array electrodes, which are general needle-type clinical electroporators for ECT, have not been evaluated systemically although these two configurations are the two basic invasive electrodes in ECT. In this study, the cell-based performances of two-types of electroporators were analyzed by using propidium iodide and bleomycin on the developed ECT testing device and their electroporaion characteristics were exploited.
Keywords :
bioMEMS; bioelectric phenomena; biomedical electrodes; cancer; cellular biophysics; microfabrication; needles; patient treatment; tumours; ECT testing device; biomedical microdevice; cancer cell; electric field strength; electrochemotherapy; electroporator; needle circular array electrode; propidium iodide; Biomedical electrodes; Breast cancer; Electrical capacitance tomography; Geometry; Humans; Needles; Neoplasms; Performance analysis; Performance evaluation; Testing; Bleomycin; Breast cance cell; Cancer therapy; Electrochemotherapy; Electroporation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
Type :
conf
DOI :
10.1109/SENSOR.2009.5285446
Filename :
5285446
Link To Document :
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