A Model of Vein Graft Intimal Hyperplasia

Author

Tran-Son-Tay, R. ; Minki Hwang ; Berceli, S.A. ; Ozaki, C.K. ; Garbey, M.

Author_Institution

Univ. of Florida, Gainesville

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

5806

Lastpage

5809

Abstract

When vein graft is implanted in the arterial system, the vein graft wall becomes thicker as an adaptive process. We have developed a model of early adaptive vein graft intimal thickening induced by shear stress. Intimal thickness and the rate of intimal thickening are expressed as functions of shear stress and time based on experimental data. The model describes the behavior of intimal thickening which is inversely related to shear stress. It also depicts the time-dependent behavior of the vein graft intimal thickening.

Keywords

biomechanics; blood vessels; cardiovascular system; cellular biophysics; haemodynamics; patient treatment; physiological models; adaptive process; arterial system; blood pressure; intimal thickening; shear stress; time-dependent behavior; vein graft intimal hyperplasia; Animals; Atherosclerosis; Blood flow; Carotid arteries; Extracellular; Hemodynamics; Implants; Muscles; Stress; Veins; Animals; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Computer Simulation; Elasticity; Graft Rejection; Hyperplasia; Male; Models, Cardiovascular; Rabbits; Shear Strength; Tunica Intima; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353667

Filename

4353667