A novel endoscopic oidrs system for non-invasive early diagnosis of esophageal cancers

In this paper, we report the design, fabrication and testing of a new endoscopic OIDRS (oblique incidence diffuse reflectance spectroscopy) system for non-invasive early diagnosis of human esophageal pre-cancers and cancers. The endoscopic OIDRS system consists of an automated data acquisition interface and a micro ldquoside-viewingrdquo optical probe. The optical probe is capable of delivering oblique light incidence onto and collecting the resulting diffuse reflectance from the interrogated tissue in parallel. The entire OIDRS system has been successfully tested to measure the diffuse reflectance from human esophageal tissue samples and achieved 100% accuracy in differentiating cancerous and benign cases.