Title :
A high sensitivity carbon nanotubes enhanced PZT diaphram-based immunosensor array
Author :
Xu, T. ; Miao, J.M. ; Wang, Z.H. ; Liu, Y.S. ; Li, C.M.
Author_Institution :
Micromachines Centre, Nanyang Technol. Univ., Singapore, Singapore
Abstract :
In this paper, a high sensitivity carbon nanotubes (CNTs) enhanced piezoelectric diaphragm-based immunosensor array for detecting anti-goat IgGs is reported. Anti-goat IgGs with 6 different concentrations was successfully detected at the same time. The average diameter of CNTs was characterized by AFM, changing from original 58 nm to 82 nm after absorbing goat IgGs. A nearly linear relationship between the frequency depression and concentration of anti-goat IgGs was obtained. The sensitivity (~227.68 Hz/ng) of the biosensor with CNTs is almost 6 times higher than that of a same type sensor without CNTs enhancement.
Keywords :
biosensors; carbon nanotubes; molecular biophysics; nanobiotechnology; piezoelectric devices; proteins; CNT enhanced immunosensor array; PZT diaphragm based immunosensor array; anti-goat IgG concentration; anti-goat IgG detection; carbon nanotubes; frequency depression; high sensitivity immunosensor array; lead zirconate titanate diaphragm; piezoelectric diaphragm; size 58 nm; size 82 nm; Biological materials; Biomedical engineering; Biomembranes; Biosensors; Carbon nanotubes; Chemical engineering; Chemical technology; Frequency; Gold; Immune system; Carbon nanotube; Diaphragm; Immunosensor; PZT;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285555
