Title :
Action potential propagation and antiarrhythmic drugs in cardiac ventricular tissue
Author :
Edler, K. ; Mendez, J.A. ; O´Shea, Kevin ; Varghese, A.
Author_Institution :
AHPCRC, Minnesota Univ., Minneapolis, MN, USA
Abstract :
The action of use-dependent drugs on electrical activity in the heart was simulated on a massively parallel supercomputer. At high concentrations, these drugs can bring about complete inhibition of electrical excitability. At lower concentrations less pronounced responses can be seen
Keywords :
bioelectric potentials; cardiology; digital simulation; physiological models; action potential propagation; antiarrhythmic drugs; cardiac model; cardiac ventricular tissue; drug effects model; electrical excitability inhibition; heart electrical activity simulation; massively parallel supercomputer; Biomembranes; Calcium; Cardiac tissue; Computational modeling; Differential equations; Drugs; Heart; Nonlinear equations; Partial differential equations; Supercomputers;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.412161
