Lab-on-chip for the isolation and characterization of circulating tumor cells

Author

Roeser, T. ; Ritzi, M. ; Drese, K.S. ; Laureyn, W. ; Chengxun Liu ; O´Sullivan, C.K. ; Ozalp, V.C. ; Fermer, C. ; Nilsson, O. ; Hauch, S. ; Albert, W. ; Borgen, E. ; Nygren, A.O.H.

Author_Institution

Inst. fuer Mikrotechnik Mainz GmbH, Mainz

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

6446

Lastpage

6448

Abstract

A consortium of seven European partners has undertaken the challenging task to develop a miniaturized system capable to isolate and characterize circulating tumor cells (CTC), which should have its use as a time and labor saving, minimally invasive tool for cancer therapy selection and monitoring and for the detection of recurrent disease. This paper reports on the general concept of the system and elaborates on the development of the different modules and their integration.

Keywords

DNA; bioMEMS; biochemistry; biomedical measurement; biosensors; cancer; cell motility; lab-on-a-chip; microfluidics; molecular biophysics; patient treatment; tumours; amplified DNA detection; cancer therapy monitoring; circulating tumor cells characterization; disease detection; lab-on-chip; mRNA isolation; microfluidics; miniaturized system; tumor cell isolation; Cancer detection; Cells (biology); Conductors; Diseases; Magnetic devices; Magnetic separation; Medical treatment; Probes; Tumors; Biosensing Techniques; Cell Separation; DNA, Complementary; Microchip Analytical Procedures; Neoplasms; Neoplastic Cells, Circulating; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Tumor Markers, Biological;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353833

Filename

4353833