Title :
Application of immune algorithm in molecular docking
Author :
Liu Zhen-yu ; Chen Ming-hua ; Kang Ling
Author_Institution :
Dept. of Comput. Sci. & Technol., Dalian Neusoft Univ. of Inf., Dalian, China
Abstract :
As a kind of intelligent algorithm, the immune algorithm is improved from genetic algorithm by adopting the density adjusting mechanism to avoid from prematurity, and by good gene resaving mechanism to speed up convergence. To test the effectiveness of the algorithm, numerical example is first adopted; and then, the algorithm is applied into molecular docking, and gain better result than DOCK6_1.
Keywords :
drugs; genetic algorithms; genetics; molecular biophysics; computer-aided drug molecule design; density adjusting mechanism; gene resaving mechanism; genetic algorithm; immune algorithm; intelligent algorithm; molecular docking; Convergence; Decision support systems; Encoding; Force; Genetic algorithms; Genetics; Radio frequency; Density adjustment; Good gene resaving mechanism; Immune algorithm; Molecular docking;
Conference_Titel :
Security, Pattern Analysis, and Cybernetics (SPAC), 2014 International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4799-5352-3
DOI :
10.1109/SPAC.2014.6982670
