Title :
Numerical model for DNA size separation using nanostructured matrix
Author :
Itoh, Shintaro ; Tagaya, Y. ; Isahaya, N. ; Fukuzawa, Kenji ; Hedong Zhang
Author_Institution :
Dept. of Micro-Nano Syst. Eng., Nagoya Univ., Nagoya, Japan
Abstract :
Numerical model for DNA separation using nanostructure was proposed. By the model calculation, we can predict the migration time of the molecule that passes through the molecular sieve. In the numerical model, we assumed the DNA molecule to be a sphere with radius Rg, which is a gyration radius, and modeled its Brownian motion by a random walk. Calculation results showed good agreement with those of experiments and we confirmed the validity of the proposed model.
Keywords :
Brownian motion; DNA; biological techniques; molecular biophysics; molecular configurations; molecular sieves; nanobiotechnology; nanoporous materials; numerical analysis; porosity; separation; Brownian motion; DNA size separation; gyration radius; molecular sieve; molecule migration time; nanostructured matrix; numerical model; random walk;
Conference_Titel :
Micro-NanoMechatronics and Human Science (MHS), 2012 International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4673-4811-9
DOI :
10.1109/MHS.2012.6492396