Implantable fluorescent hydrogel for continous blood glucose monitoring

We present a continuous glucose monitoring sensors using glucose-sensitive fluorescent dyes. We prepared microgels by copolymerizing acrylamide with the glucose sensitive fluorescent dyes. This fluorescent gel shows a high quantifiability and rapid response in the physiological glucose concentration range of 62.5 to 1000 mg/dL. Our in vivo study revealed that fluorescent intensity of the gels changed in response to in vivo blood-glucose levels. We expect this method to be useful in the development of implantable continuous monitoring systems based on fluorescent gels.